Peter E. Lobie
▌TFF3 as a Target in Oncology: from Basic Biology
Trefoil Factor 3 (TFF3) as a target in Oncology: from basic biology.
● Small secreted peptide: multiple binding effectors including CXCR4/7, LINGO2, CD147, CD44 and others.
● Highly significant increased expression in a variety of solid tumors especially breast, liver, gastric, lung, prostate, colon.
● Expression highly correlated to micrometastatic spread in a variety of cancers. Tumor expression highly associated with metastasis and RF and overall patient survival.
● TFF3 promotes cell proliferation, cell survival,oncogenicity, CSC, EMT, xenograft growth, angiogenesis, in vivo invasion and metastasis, immune modulation Homodimeric form of TFF3 stimulates cancer cell survival.